Use a comma to separate introductory words, phrases, or clauses.
A comma is used to separate introductory words (besides, however, furthermore, therefore) and introductory phrases and clauses.
A comma is used to separate introductory participial phrases, adverbial clauses, and prepositional clauses.
An appositive is a word that follows a noun and explains it.
Parenthetical expressions also explain or clarify the sentence. Some of the more common expressions are of course, I believe, after all, by the way, in my opinion, for example, to tell the truth.
Such words as however, moreover, nevertheless, otherwise, or therefore often appear parenthetically.
Non-defining clauses provide additional information about the noun they modify. These clauses are typically separated by commas.
When listing items (either words, phrases, or clauses) in a series, use commas to separate them. There are different views on whether a comma is needed before and. Some grammarians have stated that it is not needed, and some have said that adding a comma before and prevents confusion in a sentence. Whichever rule you decide to go by, make sure you are consistent throughout your writing whenever there are series of items joined by and.
When joining two complete sentences, use a comma before a coordinating conjunction (and, or, for, nor, so, but, or yet).
With place names
With the date
When only month and date are given, no comma is necessary.
When two adjectives separately modify the same noun and can be inverted and connected with and, use a comma between them.
Before quotations
He said, “I’m your best friend.”